© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

_John Dewey and Continental Philosophy_ provides a rich sampling of exchanges that could have taken place long ago between the traditions of American pragmatism and continental philosophy had the lines of communication been more open between Dewey and his European contemporaries. Since they were not, Paul Fairfield and thirteen of his colleagues seek to remedy the situation by bringing the philosophy of Dewey into conversation with several currents in continental philosophical thought, from post-Kantian idealism and the work of Friedrich (...) Nietzsche to twentieth-century phenomenology, hermeneutics, and poststructuralism. This unique volume includes discussions comparing and contrasting Dewey with the German philosophers G. W. F. Hegel, Friedrich Nietzsche, Martin Heidegger, and Hans-Georg Gadamer on such topics as phenomenology, naturalism, organicism, contextualism, and poetry. Others investigate a series of connections between Dewey and contemporary French philosophy, including the notions of subjectivity, education, and the critique of modernity in Michel Foucault; language and politics in Jacques Derrida; and the concept of experience in Gilles Deleuze. Also discussed is the question of whether we can identify traces of _Bildung_ in Dewey’s writings on education, and pragmatism’s complex relation to twentieth-century phenomenology and hermeneutics, including the problematic question of whether Heidegger was a pragmatist in any meaningful sense. Presented in intriguing pairings, these thirteen essays offer different approaches to the material that will leave readers with much to deliberate. _ John Dewey and Continental Philosophy_ demonstrates some of the many connections and opportunities for cross-traditional thinking that have long existed between Dewey and continental thought, but have been under-explored. The intersection presented here between Dewey’s pragmatism and the European traditions makes a significant contribution to continental and American philosophy and will spur new and important developments in the American philosophical debate. (shrink)

Wittgenstein’s philosophical achievement lies in the development of a new philosophical method rather than in the elaboration of a particular philosophical system. Dr Paul Johnston applies this innovative method to the central problems of moral philosophy: whether there can be ‘truth’ in ethics, or what the meaning of objectivity might mean in the context of moral deliberation. Wittgenstein and Moral Philosophy, first published in 1989, represents the first serious and rigorous attempt to apply Wittgenstein’s method to ethics. The (...) conclusions arrived at differ radically from those dominating contemporary ethical discussion, revealing an immense discrepancy between the ethical concepts employed in everyday moral decision-making and the way in which these are discussed by philosophers. Dr Johnston examines ways of eliminating this discrepancy in order to gain a clearer picture of the proper nature of moral claims, and at the same time provides new insights into Wittgenstein’s conception of philosophy. (shrink)

Wittgenstein’s philosophical achievement lies in the development of a new philosophical method rather than in the elaboration of a particular philosophical system. Dr Paul Johnston applies this innovative method to the central problems of moral philosophy: whether there can be ‘truth’ in ethics, or what the meaning of objectivity might mean in the context of moral deliberation. Wittgenstein and Moral Philosophy, first published in 1989, represents the first serious and rigorous attempt to apply Wittgenstein’s method to ethics. The (...) conclusions arrived at differ radically from those dominating contemporary ethical discussion, revealing an immense discrepancy between the ethical concepts employed in everyday moral decision-making and the way in which these are discussed by philosophers. Dr Johnston examines ways of eliminating this discrepancy in order to gain a clearer picture of the proper nature of moral claims, and at the same time provides new insights into Wittgenstein’s conception of philosophy. (shrink)

The idea of the Inner is central to our concept of a person and yet is far from being philosophically understood. This book offers a comprehensive account of Wittgenstein's work on the subject and presents a forceful challenge to contemporary views. Written in a non-technical and accessible style, it throws new light both on Wittgenstein's work and on the problem of the Inner self.

The idea of the Inner is central to our concept of a person and yet is far from being philosophically understood. This book offers a comprehensive account of Wittgenstein's work on the subject and presents a forceful challenge to contemporary views. Written in a non-technical and accessible style, it throws new light both on Wittgenstein's work and on the problem of the Inner self.

Spaces of Geographical Thought examines key ideas – like space and place - which inform the geographic imagination. The text: discusses the core conceptual vocabulary of human geography: agency: structure; state: society; culture: economy; space: place; black: white; man: woman; nature: culture; local: global; and time: space; explains the significance of these binaries in the constitution of geographic thought; and shows how many of these binaries have been interrogated and re-imagined in more recent geographical thinking. A consideration of these binaries (...) will define the concepts and situate students in the most current geographical arguments and debates. The text will be required reading for all modules on the philosophy of geography and on geographical theory. (shrink)

The idea of the inner is central to our conception of a person and is at the heart of all interaction. But how should we understand this concept, and what do we mean when we wonder what is going on inside our heads? This accessible and non-technical guide to Wittgenstein provides insight into his work in this area and on the problem of the inner. Using Wittgenstein's recently published writings on the philosophy of psychology, together with unpublished material, Paul (...) Johnston presents a thorough account of a subject that was central to Wittgenstein's later work. He shows that Wittgenstein's arguments involve a radical re-thinking of our understanding of the inner and present a challenge to contemporary views which has yet to be fully appreciated or understood. Wittgenstein demonstrates how a Wittgensteinian approach can dissolve age-old problems about the nature of consciousness and the relationship between the mind, the body, and the soul. The resulting picture of the inner, with its stress on the crucial role of language, sheds light on the direction of Wittgenstein's work and presents a stimulating and controversial alternative to more fashionable positions on the subject. (shrink)

Published one year after Forget Foucault, In the Shadow of the Silent Majorities may be the most important sociopolitical manifesto of the twentieth century: it calls for nothing less than the end of both sociology and politics. Disenfranchised revolutionaries hoped to reach the masses directly through spectacular actions, but their message merely played into the hands of the media and the state. In a media society meaning has no meaning anymore; communication merely communicates itself. Jean Baudrillard uses this last outburst (...) of ideological terrorism in Europe to showcase the end of the "Social." Once invoked by Marx as the motor of history, the masses no longer have sociological reality. In the electronic media society, all the masses can do--and all they will do--is enjoy the spectacle. In the Shadow of the Silent Majorities takes to its ultimate conclusion the "end of ideologies" experienced in Europe after the Soviet invasion of Hungary and the death of revolutionary illusions after May 1968. Ideological terrorism doesn't represent anything anymore, writes Baudrillard, not even itself. It is just the last hysterical reaction to discredited political illusions. (shrink)

Recent books by Paul Johnston, D. Z. Phillips, Philip Shields, and B. R. Tilghman all depict Wittgenstein as centrally concerned with ethics, but they range from representing his main works as expressing and advocating a particular religious-ethical outlook to arguing that his work has no ethical content but aims primarily to clarify such logical distinctions as that between ethical and empirical judgments. All four books raise the question about the moral philosopher's proper role, and each suggests a rather (...) different answer. Via the discussion of these books, I argue that Wittgenstein's stress on diversity in the ways of human life, his notion of conceptual grammar, the idea of a perspicuous representation, his lifelong involvement with art and his suggestions about its connection with morality, and his preoccupation with aspect-seeing-all suggest new possibilities of rehabilitating the historically recurrent idea that the philosopher may be a moral sage. (shrink)

Chemistry educator Alex H. Johnstone is perhaps best known for his insight that chemistry is best explained using macroscopic, submicroscopic, and symbolic perspectives. But in his writings, he stressed a broader thesis, namely that teaching should be guided by scientific research on how the brain learns: cognitive science. Since Johnstone’s retirement, science’s understanding of learning has progressed rapidly. A surprising discovery has been when solving chemistry problems of any complexity, reasoning does not work: students must apply very-well-memorized facts and algorithms. (...) Following Johnstone’s advice, we review recent discoveries of cognitive science research. Instructional strategies are recommended that cognitive studies have shown help students learn chemistry. (shrink)

_The Contradictions of Modern Moral Philosophy_ is a highly original and radical critique of contemporary moral theory. Paul Johnston demonstrates that much recent moral philosophy is confused about the fundamental issue of whether there are correct moral judgements. He shows that the standard modern approaches to ethics cannot justify - or even make much sense of - traditional moral beliefs. Applied rigorously, these approaches suggest that we should reject ethics as a set of outdated and misguided claims. Rather (...) than facing up to this conclusion, most recent moral philosophy consists of attempts to find some ways of preserving moral beliefs. This places a contradiction at the heart of moral philosophy. As a resilt it is often impossible to tell whether a contemporary philosopher ultimately rejects or endorses the idea of objective right and wrong. On the basis of a Wittgenstein approach Paul Johnston puts forward an alternative account of ethics that avoids this contradiction and recognises that the central issues of ethics cannot be resolved by conceptual analysis. He then uses this account to highlight the contradictions of important contemporary moral theorists such as Bernard Williams, Alasdair MacIntyre, Thomas Nagel and Charles Taylor. (shrink)

_The Contradictions of Modern Moral Philosophy_ is a highly original and radical critique of contemporary moral theory. Paul Johnston demonstrates that much recent moral philosophy is confused about the fundamental issue of whether there are correct moral judgements. He shows that the standard modern approaches to ethics cannot justify - or even make much sense of - traditional moral beliefs. Applied rigorously, these approaches suggest that we should reject ethics as a set of outdated and misguided claims. Rather (...) than facing up to this conclusion, most recent moral philosophy consists of attempts to find some ways of preserving moral beliefs. This places a contradiction at the heart of moral philosophy. As a resilt it is often impossible to tell whether a contemporary philosopher ultimately rejects or endorses the idea of objective right and wrong. On the basis of a Wittgenstein approach Paul Johnston puts forward an alternative account of ethics that avoids this contradiction and recognises that the central issues of ethics cannot be resolved by conceptual analysis. He then uses this account to highlight the contradictions of important contemporary moral theorists such as Bernard Williams, Alasdair MacIntyre, Thomas Nagel and Charles Taylor. (shrink)

_The Contradictions of Modern Moral Philosophy_ is a highly original and radical critique of contemporary moral theory. Paul Johnston demonstrates that much recent moral philosophy is confused about the fundamental issue of whether there are correct moral judgements. He shows that the standard modern approaches to ethics cannot justify - or even make much sense of - traditional moral beliefs. Applied rigorously, these approaches suggest that we should reject ethics as a set of outdated and misguided claims. Rather (...) than facing up to this conclusion, most recent moral philosophy consists of attempts to find some ways of preserving moral beliefs. This places a contradiction at the heart of moral philosophy. As a resilt it is often impossible to tell whether a contemporary philosopher ultimately rejects or endorses the idea of objective right and wrong. On the basis of a Wittgenstein approach Paul Johnston puts forward an alternative account of ethics that avoids this contradiction and recognises that the central issues of ethics cannot be resolved by conceptual analysis. He then uses this account to highlight the contradictions of important contemporary moral theorists such as Bernard Williams, Alasdair MacIntyre, Thomas Nagel and Charles Taylor. (shrink)

Medical tourism (MT) can be conceptualized as the intentional pursuit of non-emergency surgical interventions by patients outside their nation of residence. Despite increasing popular interest in MT, the ethical issues associated with the practice have thus far been under-examined. MT has been associated with a range of both positive and negative effects for medical tourists' home and host countries, and for the medical tourists themselves. Absent from previous explorations of MT is a clear argument of how responsibility for the harms (...) of this practice should be assigned. This paper addresses this gap by describing both backward looking liability and forward looking political responsibility for stakeholders in MT. We use a political responsibility model to develop a decision-making process for individual medical tourists and conclude that more information on the effects of MT must be developed to help patients engage in ethical MT. (shrink)

We investigated the definition, prevalence, perceived prevalence and severity of, as well as justifications for and expected responses to, academic dishonesty at the graduate level in a sample of 246 graduate students, 49 faculty, and 20 administrators. Between 2.5% and 55.1% of students self-reported engaging in academically dishonest behaviors, depending on the nature of the behavior. Students and faculty rated 40 examples of academically dishonest behaviors similarly in terms of severity, but faculty tended to underestimate the prevalence of academic dishonesty. (...) Students and faculty also reported how they would idealistically and realistically expect themselves to respond to cheating situations. Students rated 21 behaviors in terms of their likeliness to increase or decrease academically dishonest behavior. Suggestions are given for developing a climate or culture of academic integrity to address academic dishonesty. (shrink)

The book roots corruption in the idea of a departure from conventional standards, and thus offers an account not only of its corrosiveness but also of its malleability and controversiality. In the course of a broadranging exploration, it examines various links between private and public corruption, connecting the latter with other social and political structures.

In recent years it has become popular to model putative refutations of skepticism on Kant's answer to Hume, that is, on transcendental arguments purporting to show that the skeptical theses presupposes essential features of the very conceptual scheme they call into question. In his book, Oneself as Another, Paul Ricoeur makes the claim that transcendental considerations of the sort invalidate Edmund Husserl's foundationalist epistemological enterprise, that of uncovering the genesis of primitive concepts of oneself, world, and others in a (...) primordial solipsistic stage from which all trace of others is excluded. According to Ricoeur the concept of others must be presupposed throughout. This paper examines the experiential evidence for four of the transcendental arguments endorsed by Ricoeur, each treating one of four key concepts--the concept of oneself as subject, that of one's flesh, that of one's body, and that of other selves. It finds that in each case Ricoeur’s argument fails, and that in each case Husserl is right to claim that a rudimentary nonlinguistic concept may arise within the confines of first-person perceptual experience. The paper then briefly examines the source of Ricoeur's erroneous evaluation. (shrink)

John Paul II is often misread as more of a philosopher than a theologian. But his Theology of the Body, rightly read, is in its entirety an exercise in exegesis. By focusing on the Bible, he gives a more fully theological account of his topic, one focused on the mystery of redemption by grace, rather than on merely human efforts.

Rick Johnstone's plea for liberal federalism and a supranational mechanism for enforcing “human rights” is reminiscent of what Thomas Hobbes said about “Christian commonwealths.” Behind their appeal to universal morality and religious doctrine was the frenzied attempt to shift rule “from Christian kings and sovereign assemblies absolute in their own territories” to “one Vicar of Christ, constituted of the universal church, to be judged, condemned, or deposed, or put to death as he shall think expedient, or necessary, for the common (...) good.” Johnstone is proposing or justifying a similar shift of authority for existing sovereign states to self-appointed vicars of…. (shrink)

2003 Paul Bunge Prize of the Hans R. Jenemann Foundation for the History of Scientific Instruments Judging the brightness and color of light has long been contentious. Alternately described as impossible and routine, it was beset by problems both technical and social. How trustworthy could such measurements be? Was the best standard of intensity a gas lamp, an incandescent bulb, or a glowing pool of molten metal? And how much did the answers depend on the background of the specialist? (...) A History of Light and Colour Measurement: Science in the Shadows is a history of the hidden workings of physical science-a technical endeavor embedded in a social context. It argues that this "undisciplined" subject, straddling academia, commerce, and regulation, may be typical not only of 20th century science, but of its future. Attracting scientists, engineers, industrialists, and artists, the developing subject produced a new breed of practitioners having mixed provenance. The new measurers of light had to decide the shape not only of their specialism but of their careers: were they to be a part of physics, engineering, or psychology? The physical scientists who dominated the subject into the early 20th century made their central aim the replacement of the problematic human eye with physical detectors of light. For psychologists between the wars, though, describing the complexity of color was more important than quantifying a handful of its dimensions. And after WWII, military designers shaped the subject of radiometry and subsumed photometry and colorimetry within it. Never attaining a professional cachet, these various specialists moved fluidly between science and technology; through government, industry, and administration. (shrink)

Paul Gottfried and Paul Piccone wrongly confuse liberal activism with liberal absolutism, and anti-genocidal interventionism with Western imperialism. Gottfried claims that human rights are just “pious noise signifying whatever journalists or victimologists want it to mean in a particular situation,” manipulated by the self-appointed vicars of the church of “human rights,” whose “new theocratic world government” means a “reduction of morality to trendiness.” Trendy theocrats? Is there some contradiction here? In his various comments on my work, and his (...) critique of Victor Zaslavsky's views on totalitarianism,1 Piccone rejects universal human rights and the liberal critique of totalitarian states—a theme echoed…. (shrink)

The main focus of this book is on philosophy of religion-in-general instead of on the philosophy of a particular religion or family of religions. For example, in the first of four main parts of the book, J. L. Schellenberg and Robert McKim write chapters on future progress in religion. Hopefully, their efforts will jump-start work in the field on this important but neglected topic. The next part of the book (as well as the book's final chapter) addresses the issue of (...) life after death. Mark Johnston follows the demands of morality wherever they lead, and arrives at a highly original conception of the after- (or elsewhere-) life, one that involves neither the resurrection of the body nor the survival of an immaterial soul. Dean Zimmerman, in his chapter, makes it clear that he will not be joining Johnston on this trip, though in some sense he arrives at the same destination by a different route. In the third part of the book, Mark Murphy pursues a highly unconventional approach to the problem of evil: he tries to solve it by denying that an absolutely perfect being must be morally perfect. Laura Ekstrom pushes back, arguing that a perfect God would have, not only justifying, but requiring reasons to prevent setbacks to the well-being of Her sentient creatures. The final part of the book, which consists of three chapters, addresses an additional topic in the philosophy of religion-in-general, namely, alternative concepts of God. Tim Mulgan defends a disjunction of two positions, one of which involves a conception of God that is very much like Murphy's, and the other of which, a form of axiarchism, is similar in some ways (but dissimilar in others) to the conception of God defended by Fiona Ellis in the chapter following Mulgan's. Although Mulgan, unlike Murphy, claims that the God he describes is morally perfect, he would agree with Murphy that God is not motivated by any moral requirements to prevent setbacks to our well-being. Ellis is unhappy with Mulgan's spin on classical theism in part because of its commitment to supernaturalism. Both she and Paul Draper, in the final two chapters of the book, attempt to articulate ideas of God that are compatible with the naturalism that some believe will guide religion into the future instead of signing its death warrant. However, Ellis and Draper pursue their common goal in opposite ways, Ellis by making God more abstract than Mulgan's God and Draper by making God more concrete. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Some Suggestions about the Moral Philosophy of George Berkeley* PAUL J. OLSCAMP WHILE TRAVELLINGIN ITALYin 1716, Berkeley lost the second part of his Principles of Human Knowledge. Much later he wrote to Dr. Johnson in America, saying that he did not have the energy to do something so disagreeable as writing the same thing twice? This manuscript contained Berkeley's ethics and metaphysics, but in spite of its loss, (...) there is much to be learned about Berkeley's moral philosophy from his extant writings. Surprisingly, very little has been written about Berkeley's ethics, and what has been written usually concentrates on Passive Obedience and virtually ignores the rest of his worksY Most of the terminology now used to classify and criticize ethical theories was, of course, unknown to Berkeley. In spite of this, much of what he says may be fruitfully compared with some of the claims of modern ethicists. I shall try to show that many of his claims might have been strikingly modern, a In this paper however, I can only deal with what would now be called the normative part of Berkeley's theory, so, perhaps, it would be of some use to give a general *All references to Berkeley's writings are to the Jessop and Luee edition, The Works o] George Berkeley, Bishop o] Cloyne (9 vols.; London: Nelson and Sons Ltd., 1948). I shall abbreviate the titles of the works in this collection as follows: A/c. for A/~phron, or the Minute Ptdlosopher; DraJt for The First Dra]~ o] the Introduction to the Priuciple8 o] Human Knowledge; Principles for The Principles o] Human Knowledge; P.O. for Passive Obedience; Disc. for A Discourse to the Macistrates; T.V. for An Essay Towards a New Theory o] Vision; T.V~E. for The Theory o] Vision Vindicated and Explained; P.C. for philosophical Commentaries; Corr ]or Philosophical Correspondence; DHP for Three Dialooucs Between Hylas and Philonous. I am deeply indebted to Professor Richard T. Garner for his help in the preparation of thispaper. 1Corr., II, 282. 'The other references are: C. D. Broad, "Berkeley's Theory of Morals," Revue Internationale de Philosophie (1953); Graham P. Conroy, "Berkeley on Moral Demonstration, Journal o] the HisLory o] Ideas, XXII (1961), and Conroy's doctoral dissertation, Language and Morals in Berkeley's Philosophy (Berkeley, 1957); H. D. Aiken, "The Fate of Philosophy in the Twentieth Century," The Kenyon Review (Spring, 1962); kvrum Stroll, The Emotive Theory o] Ethics (Berkeley and Los Angeles: University of California Press, 1954); Ernest Albee, A History o] English Utilitarianism (London: Alien & Unwin, 1901), chap. xv; I. A. Richards and C. K. Ogden, The Meaning o] Meaning (New York: Harcourt Brace and Co., 1923), p. 42; P. J. Olscamp, A Berlceleyan Analysis o] the Uses o] Language in Ethics, (doctoral dissertation, University of Rochester, 1962); W. V. Denard, "Berkeley's Theological Utilitarianism," Acres de XI" eongr~s internationale de philosophic, XIII (1953), 87-93; G. A. Johnston, "The Development of Berkeley's Ethical Theory," Philosophical Review, XXIV, 419-430; H. W. Orange, "Berkeley as a Moral Philosopher," Mind, XV (old series), 514-523. =The definitions of any technical terms I may use will be found in William K. Frankena, Ethies, (Englewood Cliffs, New Jersey: Prentice-Hall Foundations of Philosophy Series, 1963). [147] 148 HISTORY OF PHILOSOPHY outline of the main features of what I think his entire system would have been, before examining part of it in more detail. Berkeley was first and last a Christian clergyman, and he therefore believed in the existence of a personal, wise, and benevolent God whose being was relevant to our daily lives. He was convinced that the natural world provides evidence for this belief, evidence as sound as that which we have for the existence of other minds. Given that the esse of objects consists in their being perceived, that only minds are active, and that no human perceiver perceives all things at all times, it follows that a cosmic mind maintains the universe it created. Moreover, the system of nature is not random, but regular; it is, in fact, a divine language in which God makes his intentions known to us, and demonstrates his wisdom... (shrink)

The early twentieth century saw the rise of various movements and communities in response to a perceived crisis in a western modernity that many contemporaries viewed as decadent and in urgent need of social, cultural, and spiritual renewal. In Britain in particular, several groups of traditional artisans expressed their rejection of modernity by leaving the city to form small artistic communities. Such community experiments often had their roots in the nineteeth-century Arts and Crafts movement, a background shared by the founding (...) members of the community at Ditchling in Sussex — Eric Gill, Douglas (Hilary) Pepler, and Edward Johnston — but augmented by an increasing commitment to Roman Catholicism on the part of Gill and Pepler. The Ditchling group’s commitments to traditional handicrafts and the Church made their relationship to modernism tentative and difficult, but some members at least were familiar with artistic developments in the wider world. In particular, Eric Gill would reject modernism at Ditchling, while David Jones would embrace it to assert his artistic and spiritual independence. (shrink)

Recent philosophical reexaminations of sacred texts have focused almost exclusively on the Christian New Testament, and Paul in particular. _The Book of Job and the Immanent Genesis of Transcendence _revives the enduring philosophical relevance and political urgency of the book of Job and thus contributes to the recent “turn toward religion” among philosophers such as Slavoj Žžk and Alain Badiou. Job is often understood to be a trite folktale about human limitation in the face of confounding and absolute transcendence; (...) on the contrary, Hankins demonstrates that Job is a drama about the struggle to create a just and viable life in a material world that is ontologically incomplete and consequently open to radical, unpredictable transformation. Job’s abiding legacy for any future materialist theology becomes clear as Hankins analyzes Job’s dramatizations of a transcendence that is not externally opposed to but that emerges from an ontologically incomplete material world. (shrink)

Appraisal theories of emotions have gained widespread acceptance in the field of emotion research (for a recent overview, see, e.g., Scherer, Schorr, & Johnstone, 2001). In these theories, it is as...

Should a principle of charity be applied to the interpretation of the colour concepts exercised in visual experience? We think not. We shall argue, for one thing, that the grounds for applying a principle of charity are lacking in the case of colour concepts. More importantly, we shall argue that attempts at giving the experience of colour a charitable interpretation either fail to respect obvious features of that experience or fail to interpret it charitably, after all. Charity to visual experience (...) is therefore no motive for resisting the natural, Galilean response to a scientific understanding of light and vision. The best interpretation of colour experience ends up convicting it of widespread and systematic error. (shrink)

The paper asks under what conditions deductive reasoning transmits justification from its premises to its conclusion. It argues that both standard externalist and standard internalist accounts of this phenomenon fail. The nature of this failure is taken to indicate the way forward: basic forms of deductive reasoning must justify by being instances of 'blind but blameless' reasoning. Finally, the paper explores the suggestion that an inferentialist account of the logical constants can help explain how such reasoning is possible.

Samuelson's text was first published in 1948, and it immediately became the authority for the principles of economics courses. The book continues to be the standard-bearer for principles courses, and this revision continues to be a clear, accurate, and interesting introduction to modern economics principles. Bill Nordhaus is now the primary author of this text, and he has revised the book to be as current and relevant as ever.

This volume presents a series of influential essays by Paul Boghossian on the theory of content and on its relation to the phenomenon of a priori knowledge. The essays are organized under four headings: the nature of content; content and self-knowledge; knowledge, content, and the a priori; and colour concepts.

In the latest edition of their popular overview text, Erickson and Murphy continue to provide a comprehensive, affordable, and accessible introduction to anthropological theory from antiquity to the present.

To claim that Hayden White has yet to be read seriously as a philosopher of history might seem false on the face of it. But do tropes and the rest provide any epistemic rationale for differing representations of historical events found in histories? As an explanation of White’s influence on philosophy of history, such a proffered emphasis only generates a puzzle with regard to taking White seriously, and not an answer to the question of why his efforts should be worthy (...) of any philosophical attention at all. For what makes his emphasis on narrative structure and its associated tropes of philosophical relevance? What, it may well be asked, did any theory that draws its categories from a stock provided by literary criticism contribute to explicating problems with regard to the warranting of claims about knowledge, explanation, or causation that represent those concerns that philosophy typically brings to this field? Robert Doran’s anthologizing of previously uncollected pieces, ranging as they do over a literal half-century of White’s published work, offers an opportunity to identify explicitly those philosophical themes and arguments that regularly and prominently feature there. Moreover, White’s essays in this volume demonstrate a credible knowledge of and interest in mainstream analytic philosophers of his era and also reveal White as deeply influenced by or well acquainted with other important philosophers of history. White thus invites a reading of his work as philosophy, and this volume presents the opportunity for accepting it as such. (shrink)

Weight-gain in psychiatric populations is a common clinical challenge. Many patients suffering from mental disorders, when exposed to psychotropic medications, gain significant weight with or without other side-effects. In addition to reducing the patients' willingness to comply with treatment, this weight-gain may create added psychological or physiological problems that need to be addressed. Thus, it is critical that clinicians take precautions to monitor and control weight-gain and take into account and treat all problems facing an individual. In this review, we (...) examine some of the key issues surrounding weight-gain in individuals suffering from mental disorders for contemporary practitioners in community clinics. We describe some factors known to make certain patients more susceptible to treatment-induced weight-gain and mechanisms implicated in this process. We also highlight a few psychological and pharmacological interventions that have proven effective in weight management. Importantly, we provide critical steps for management and prevention of weight-gain and related issues in the clinical practice of psychopharmacology. (shrink)

Compatibilism combines an externalist view of mental content with a doctrine of privileged self‐knowledge. The essay presents a reductio of compatibilism by arguing that if compatibilism were true, we would be in a position to know certain facts about the world a priori, facts that no one can reasonably believe are knowable a priori. Whether this should be taken to cast doubt on externalism or privileged self‐knowledge is not discussed. Consideration is given to the ’empty case’—the case in which a (...) thinker expresses what he takes to be a genuine thought concerning a natural kind but where there is in fact no relevant natural kind, so that the putative natural kind term fails to refer. It is argued that, in such a case, on an externalist conception of natural kind terms, the thinker is deluded in taking himself to be expressing a complete thought, and that such delusions are not compatible with privileged self‐knowledge. (shrink)

This paper argues that, given a certain apparently inevitable thesis about content, we could not know our own minds. The thesis is that the content of a thought is determined by its relational properties.

This comprehensive anthology offers over 40 readings that are critical to the understanding of anthropological theory and the development of anthropology as an academic discipline. The fourth edition maintains a strong focus on the "four-field" roots of the discipline in North America but has been reorganized with a new section on twenty-first-century theory, including coverage of postcolonial and public anthropology. New key terms and introductions accompany each reading and a revamped glossary makes the book more student-friendly. Used on its own, (...) or together with the overview text A History of Anthropological Theory, Fourth Edition, this anthology offers a flexible and unrivaled introduction to anthropological theory that reflects not only the history but also the changing nature of the discipline today. For additional resources, visit the "Teaching Theory" page at www.utpteachingculture.com. (shrink)

In this chapter a new problem about rule-following is outlined, one that is distinct both from Kripke’s and Wright’s versions of the problem. This new problem cannot be correctly responsed to, as Kripke’s can, by invoking Wright’s Intentional Account of rule-following. The upshot might be called, following Kant, an antinomy of pure reason: we both must — and cannot — make sense of someone’s following a rule. The chapter explores various ways out of this antinomy without here endorsing any of (...) them. (shrink)

It is very common these days to come across the claim that the notions of mental content and linguistic meaning are normative notions. In the work of many philosophers, it plays a pivotal role. Saul Kripke made it the centerpiece of his influential discussion of Wittgenstein’s treatment of rulefollowing and private language; he used it to argue that the notions of meaning and content cannot be understood in naturalistic terms. Kripke’s formulations tend to be in terms of the notion of (...) linguistic meaning, but his argumentative strategy makes it clear that he holds both versions of the claim.... (shrink)

ABSTRACTThis essay offers a reconfiguration of the possibility‐space of positions regarding the metaphysics and epistemology associated with historical knowledge. A tradition within analytic philosophy from Danto to Dummett attempts to answer questions about the reality of the past on the basis of two shared assumptions. The first takes individual statements as the relevant unit of semantic and philosophical analysis. The second presumes that variants of realism and antirealism about the past exhaust the metaphysical options . This essay argues that both (...) of these assumptions should be rejected. It develops as an alternative an irrealist account of history, a view based in part on work by Leon Goldstein and Ian Hacking. On an irrealist view, historical claims ought to be treated as subject to the same conditions and caveats that apply to any theory of empirical or scientific knowledge. Irrealism argues for pasts as made and not found. The argument emphasizes the priority of classification over perception in the order of understanding and so verification. Because nothing a priori anchors practices of classification, no sense can be attached to claims that some single structure must or does determine what events take place in human history. Irrealism denies to realism the very intelligibility of any imagined view from nowhere, that is, a determinately configured past subsisting sub specie aeternitatis. A plurality of pasts exists because constituting a past always depends to some degree on socially mediated negotiations of a fit between descriptions and experience. (shrink)